Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
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چکیده
منابع مشابه
Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
BACKGROUND Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS We included 792 Normative Aging Study participants with 1-4 BTL measurements from 1999 to 2012. We used...
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Background Obesity has been linked with shorter telomere length, both of which have been implicated in ageing, but the impact of early life adiposity on telomere length is unclear. Methods We included 2,479 participants from the MRC National Survey of Health and Development with measurements of body mass index (BMI), waist and hip circumference and leukocyte telomere length (LTL) at age 53, o...
متن کاملTelomere Length and Aging
Telomeres, the TTAGGG tandem repeats at the ends of chromosomes, become progressively shortened with each replication of cultured human somatic cells (reviewed in Wong and Collins (Wong & Collins 2003)) until a critical length is achieved, at which point the cell enters replicative senescence. This situation can be reversed by the enzyme named telomerase that is responsible for Telomere Length ...
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Age-associated telomere shortening is a well documented feature of peripheral blood cells in human population studies, but it is not known to what extent these data can be transferred to the individual level. Telomere length (TL) in two blood samples taken at approximately 10 years interval from 959 individuals was investigated using real-time PCR. TL was also measured in 13 families from a mul...
متن کاملTelomere length and reproductive aging
BACKGROUND Rate of reproductive aging may be related to rate of biological aging. Thus, indicators of aging, such as short telomere length, may be more frequent in women with a history suggestive of premature reproductive senescence. METHODS Telomere-specific quantitative PCR was used to assess telomere length in two groups of women with evidence of reproductive aging: (i) patients with idiop...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2015
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2015.04.008